Olink Reveal is the newest solution in high-throughput proteomics, leveraging Olink’s well-established Proximity Extension Assay (PEA) technology combined with next-generation sequencing (NGS) readouts. Similar to the Olink Explore platform but featuring a new, focused assay library and a cost-effective workflow, Olink Reveal empowers researchers to measure over 1,000 proteins from just 4 µL of sample.
Olink Reveal assay library
The Olink Reveal assay library was carefully curated to provide:
- Broad pathway coverage: Capturing 100% of top biological pathways from Reactome and 64% of all pathways.
- Immune response coverage: Including 537 inflammatory markers that cover 96% of immune response pathways.
- Genetic linkage with cis-pQTLs: Including over 700 proteins featuring documented cis-pQTLs, genetic variants located near the gene encoding each protein, offering insights into disease mechanisms.
- Disease associations: Ensuring comprehensive representation of proteins with the highest disease risk scores from the UK Biobank proteomics project.
Key benefits
Olink Reveal delivers femtogram-per-milliliter (fg/mL) sensitivity with <8% CV between plates and across different sites, Olink Reveal also demonstrates a high correlation (R > 0.94) with Olink Explore. Finally, Its cost-effective setup enables the simultaneous analysis of 86 samples for over 1,000 protein targets in a single run, making it an ideal screening tool for large cohort studies, revealing disease signatures among various groups and inflammation mechanisms.
By combining extensive pathway coverage and data quality in a cost-effective manner, Olink Reveal revolutionizes modern proteomics. Olink Reveal is expected to help researchers explore, understand, and ultimately advance disease research, paving the way for new biomarker discoveries for diagnostics and personalized medicine.
Olink Reveal by Protavio
At Protavio, our mission is to drive better health through innovation in proteomics. As a certified service provider for Olink Explore, we are proud to incorporate Olink Reveal into our portfolio, enabling researchers to leverage the latest advancements in protein biomarker discovery. By uniting our deep proteomics expertise with Olink’s innovative platforms, we deliver comprehensive solutions that accelerate disease research, support diagnostic assay development, and ultimately advance precision health.
For more information on how Olink Reveal can advance your research, contact us.